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TABLE 4 Development of MM therapeutic agents targeting ferroptosis-related pathways and summary of studies on ferroptosis regulation by approved MM drugs in other diseases

Under hypoxic conditions, PHD enzymes are inactivated, stabilizing HIF-1 and HIF-2, which then translocate to the nucleus

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The viral protein encoded by ORF6 potently inhibits nuclear trafficking and helps viral evasion of IFN-mediated host defenses 52

2.8.6 Relationship between GSH and brain excitability (GABA+ and Glx) A graph theory approach was used to examine the relationship between GSH, GABA+ and Glx in three conditions: (a) baseline, (b) task and (c) modulation (metabolic change from baseline to task)

Robust, head-to-head studies are needed to clarify the therapeutic potential and mechanistic diversity of these compounds before their clinical application in DOR management can be meaningfully assessed