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3.2.2 In vivo study In vivo studies conducted in KOA animal models constitute a critical component in evaluating the efficacy and safety of intra-articular PBM

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Rather than dosing cells with a chemically synthesized 24-amino-acid fragment, this line of research used viral vectors to make muscle fibers themselves express the rodent IGF-I isoforms (IGF-IA and IGF-IB, whose E-peptides are the rodent counterparts of the human Ea and Eb/Ec extensions)