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The most common side effects of chronic vitamin A toxicity are: Vision problems Joint and bone pain Loss of appetite Nausea and vomiting Sensitivity to sunlight Hair loss Headaches Dry skin Liver damage Jaundice Delayed growth Decreased appetite Confusion Itchy skin Toxicity can adversely affect the health of pregnant women and their babies and may lead to fetal developmental abnormalities

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Depression patients exhibit reduced parasympathetic activity and relative sympathetic hyperactivity, and this autonomic imbalance inhibits the generation and propagation of propulsive intestinal contractions (Bonaz et al., 2017)

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Furthermore, both human primary CD34+ cells treated with IS and a mouse model with 5/6 Nx exhibited a blockage at the BFU-E stage of erythropoiesis