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NAD+ does more than produce energy - it acts as a co-substrate for enzymes such as sirtuins and PARPs that maintain DNA repair and genomic stability

Received: Accepted: Published: Version of record: DOI: Comments Very impressive paper

We also demonstrate that SCLC cells associated with high ASCL1 expression are more susceptible to the blockage of mitochondrial respiratory complex I (NADH dehydrogenase) and, moreover, that non-ASCL1-driven cells are more susceptible to glutaminolysis inhibition, which may allow future subtype-specific personalized therapy

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A gama inclui opes com e sem estimulantes

GCaru: Conceptualization, Writing review & editing, Writing original draft, Project administration, Supervision, Visualization