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257,259 Moreover, JAK3 mutations have been shown to lead to severe immunodeficiencies, whereas STAT3 mutations impair IL-17 production, which increases susceptibility to bacterial and fungal infections

Hambright et al., 2017

Camerota F, Castori M, Celletti C, Colotto M, Amato S, Colella A, Curione M, Danese C

It was historically used in human medicine but is now primarily used in veterinary medicine, particularly for horses, to promote muscle growth, improve nitrogen balance, and enhance appetite

J Phys Chem 117: 7655-7674

The gap between BPC-157's animal research profile and its human evidence base has long been striking