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found that the human plasma copper binding peptide GHK added to cultures of mesenchymal stem cells increased their concentrations of VEGF and basic fibroblast growth factor, and also increased endothelial cell proliferation, migration and tubule formation

Key facts from Pickarts original studies: GHK-Cu exists in the plasma of all healthy adults The concentration decreases with age , from ~200 ng/ml in 20-year-olds to ~80 ng/ml in 60-year-olds This decline correlates with the age-related loss of regenerative capacity of tissue Cu is essential for the biological activity, GHK without copper has a dramatically weaker effect These original observations launched a 50-year research program that today covers thousands of publications in dermatology, wound healing, ageing research and regenerative medicine