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NAD+ is also essential for activating proteins called sirtuins, which are involved in aging, inflammation regulation, and cellular repair processes

But as injections, especially administered by untrained hands, they could trigger side effects like rashes, hives and chills, say dermatologists The latest streaming series, Made In Heaven 2 , has once again highlighted the dangers of getting skin-lightening treatments done at the salon or self-proclaimed beauty clinics which may not have trained and clinical dermatologists to do the job or administer the right dosage

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Ultracentrifugation, widely regarded as the gold standard, often co-isolates contaminating proteins, small microvesicles, and apoptotic bodies, leading to heterogeneous preparations with variable purity [133-134]

Competing interest The authors declare no competing interests