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Reported side effects are generally mild in supervised use, such as injection site reactions, but the real risks come from unregulated products, incorrect self dosing, and skipping medical evaluation

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Most studies have chosen to target H3R, a presynaptic autoreceptor that regulates dopamine, acetylcholine, and histamine release via negative feedback, which has also been associated with other neurologic disorders such as Alzheimers disease and attention deficit hyperactive disorder (ADHD) [59,60]

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Nat Rev Rheumatol (2018) 14:52841