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Description

Nat Methods 2006

In a sepsis model created by cecal ligation and puncture (CLP) in mice, decreased SIRT1 and SIRT3 activity was associated with mitochondrial damage (104)

System Xc- facilitates the 1:1 exchange of cystine and glutamate across the cell membrane (9)

Metabolites were annotated against METLIN (via Progenesis QI), Human Metabolome Database (HMDB), and an in-house library with theoretical fragment matching