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The BBB is formed by endothelial cells lining cerebral blood vessels and supported by surrounding cells including astrocytes, pericytes, microglia, neurons and the acellular basement membrane 19

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For example, PEG-fusion restores intra-axonal dye diffusion, conduction of compound action potentials across the repair site, prevents the Wallerian degeneration of many severed distal axonal segments, maintains muscle innervation and retrograde transport to spinal motoneurons, prevents motoneuron somal/dendritic atrophy, and remarkably improves locomotor behavioral recovery (Riley et al., 2015