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Two bioinformatics analyses identified three (ACO1, HCRA1, and MMD) and six (CYBB, CTSB, SLC38A1, TLR4, PEX2, and ABCC1) FRGs, respectively, with strong diagnostic specificity in the orbital fibroblasts of thyroid-associated orbitopathy (TAO) patients ( In the context of B cells, NOX4 and PARP14, both of which were identified as common ferroptosis differentially expressed genes, were associated with immune infiltration of activated B cells in DR patients ( Owing to the presence of BRB and the absence of lymphatics maintaining the immune privilege of the retina, various glial cells (Mller cells, astrocytes, etc.), despite not being classified as immune cells, contribute extensively to the ocular immunity