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[21] Adjunctive agents, such as beta-blockers for rapid heart rate (tachycardia), anticonvulsants for neural excitability, and trazodone for insomnia, may help reduce the risk of severe withdrawal complications

doi: 10.3171/2014.9.FOCUS14494

In a related study, Meihui Zhang et al

Surgical procedures of the CCI model The chronic constriction injury (CCI) model of the sciatic nerve was established to induce sciatic NP in mice, following a previously described protocol with minor modifications 27