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Treatment of the cells with SFN significantly suppressed hippuric acid-mediated ROS and H 2 O 2 production, and upregulated the antioxidant proteins NRF2, HO-1, and NQO1 [123]

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doi: 10.1021/ja4115924 230 TroxellB.HassanH

Across AD, PD, and ALS, chronic microglial activation is a common pathological denominator while originally meant to contain damage, this activation ultimately propagates disease progression when continuously stimulated (104)