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27 Under hypoxic conditions, intervened by hypoxia-inducible factor (HIF), there is a reduction in hepcidin expression, which promotes iron release

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Recent studies indicate that radiation exposure increases intracellular iron concentration by dampening the iron-sulfur center-containing proteins

doi: 10.1371/journal.pone.0097330 52 MartinsPNANeuhausP

As understanding of PCOS evolves, IR is increasingly recognized as a key factor in the pathogenesis of the disorder, resulting in the widespread utilization of metformin, a medication that enhances insulin sensitivity, for the management of PCOS