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Lee SWL, Campisi M, Osaki T, Possenti L, Mattu C, Adriani G, et al

Exclusion criteria included: unclear diagnosis of HCC, portal vein tumor thrombosis or portal vein compression by neoplasm

Within this network, NOX2-MPO(myeloid) and XO/eNOS (endothelial) amplify ROS signals in a secondary manner, driving the ferroptosis cascade

The second tier of evidence consists of documentation of 1 or more of the following signs of hemolysis via: 1) Hyperbilirubinemia (which will only occur if bilirubin production exceeds liver uptake or cholestasis developes), excessive bilirubinuria (indicating cholestasis) or icterus without evidence of hepatic disease or biliary obstruction/rupture or sepsis, 2) Hemoglobinemia, 3) Hemoglobinuria, or 4) Ghost RBCs (not specific for intravascular hemolysis)