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The herbal combination of Gualou and Xiebai can inhibit the P2RY12-PI3K signaling pathway, enhance LC3II expression in adipose tissue, reduce p62 and plin2 levels and reduce lipid droplets formation and foam cell derivation in VSMC by inhibiting lipophagy [211]

ORP5/8 facilitate membrane lipid remodeling by directing phosphatidylserine (PS) to mitochondria, where it is converted to phosphatidylethanolamine (PE) at the inner mitochondrial membrane (IMM) through coordinated interactions with OMM proteins such as PTPIP51 or Sam50 [78]

It can increase serum insulin and reduce blood glucose levels in diabetic mice [184]

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NeuroImage 135:214222 Acknowledgements We are grateful to Professor P.L

excessive use may lead to kidney strain in predisposed individuals