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Furthermore, in the spleen, M-MDSCs can differentiate into DCs upon STAT3 inhibition

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Furthermore, macrophage activation by LPS is dependent on glycolysis, as inhibition of glycolysis with 2-deoxyglucose (2DG) decreases the inflammatory response, whereas inhibitors of mitochondrial respiration have no such effect, consistent with the fact that oxidative metabolism is already shut down under such conditions 38

The in vivo evidence for regulated necrosis

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Li J, Tang G, Qin W, Yang R, Ma R, Ma B, Wei J, Lv H, Jiang Y (2018a) Toxic effects of arsenic trioxide on Echinococcus granulosus protoscoleces through ROS production, and Ca 2+ -ER stress-dependent apoptosis