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Recent evidence suggests the existence of a third COX isoform, designated COX-3 , with roles in mediating pain and fever, and subject to inhibition by acetaminophen

Since the retina is considered an extension of the brain, its unique structure allows it to exhibit similar immune response mechanisms to the brain

doi: 10.1074/jbc.M116.731703 161 MlzerCWallnerMKernCTosevskaASchwarzUZadnikarRet al

Nat Cell Biol 2000, 2: 423427

10.1073/pnas.1201380109

The two other products contain a lower amount (0.01%), mainly to provide antioxidant protection and to support other brightening ingredients, such as glutathione and niacinamide