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Ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, holds therapeutic potential

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Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

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Collectively, these studies establish the pyrrolo [2,3- d ] pyrimidine analog AGF347 as an exciting prototype for multi-targeting mitochondrial and cytosolic C1 metabolism for cancer, with substantial promise for overcoming resistance to current anticancer therapies [12]