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Long-term deficiency might lead to irreversible damage to the brain and nervous system

Cell 169 (1), 132147.e16

As both an endogenous antioxidant and a regulator of mitochondrial function, melatonin uniquely bridges circadian regulation and redox homeostasis, positioning oxidative stress as a downstream consequence of circadian and melatonergic decline in aging

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We demonstrate that cells undergoing reprogramming experience an elevated demand for vitamin B 12 , associated with increased levels of the B 12 -dependent enzyme MS and increased expression of Cd320 , which encodes the cellular vitamin B 12 uptake receptor