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Both the polyol pathway and the protein glycation process favor the generation of advanced glycation end products (AGEs), which further worsen oxidative stress (5)

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Reported observations include: Transient redness or itching at the injection site Mild fatigue in the first 57 days of loading Temporary appetite increase Vivid dreams in evening dosing protocols Discontinue research use and consult relevant occupational-safety protocols if unusual reactions occur

Considering the duration of clinical trials for discovering cancer chemopreventive drugs, selecting appropriate preclinical research models that fully simulate the process of human tumor occurrence and development may result in greater success of candidate compounds in clinical trials