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The most commonly reported indications are nausea and vomiting, urinary tract infections, preparation for and/or facilitation of labor, common cold or flu, gastrointestinal problems (e.g., constipation, flatulence), pain conditions, improvement of fetal outcomes, prevention of miscarriage, relief of anxiety, treatment and/or prevention of anemia, and treatment of edema (Kennedy et al., 2013

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Lachner, M., OCarroll, D., Rea, S., Mechtler, K

Biomarkers are important in confirming AD pathology and guiding targeted therapies 6

H.HanL.et al (2019)

3.3 Pathological markers: axonal degeneration, demyelination, and microvascular damage Current studies consistently indicate that the core pathological manifestations of DPN include: axonal degeneration (Galiero et al., 2023), Schwann cell-mediated demyelination (Chong and Souayah, 2025), and neurovascular microcirculation dysfunction (Zhu et al., 2024), which together constitute the major forms of damage