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An intermediate research compound, AOD9401, was studied in parallel and contributed substantially to the mechanistic literature during this period

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In findings from a phase 2a trial that were presented at the American Diabetes Association Scientific Sessions and simultaneously published in The Lancet , 71% of adults receiving coadministered cagrilintide and semaglutide 2.4 mg, dubbed CagriSema (Novo Nordisk), lost at least 10% of their body weight, and 89% of adults achieved an HbA1c of less than 7% with the combination therapy

Each line was initially differentiated to DE under the 4 conditions used in the initial EP screen, and after DE induction the cells were then differentiated to smHLCs 11

Disclosure of interest: EH receives funding from the Research Foundation Flanders (FWO) and the Belgian American Educational Foundation (BAEF)