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This is currently uncertain, with many unexplained mechanisms between AT, GPX4, and immune cells

Additionally, in one animal study, -linolenic acid (a plant-derived omega-3 fatty acid) suppressed expression of adhesion molecules , which are important in inflammation, immune responses and in intracellular signaling events (Golias 2011

This mechanism was further examined in in vitro model, where it was shown that benfotiamine suppresses -amyloid production in HEK cells, while also enhancing the ratio of phosphorylated GSK/GSK, thus inhibiting its activity [73]

However, this does not give a relevant impact on the amount of selenium in animal products because animals maintain stable selenium tissue concentrations through homeostatic mechanisms [68]