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Deters, M., Klabunde, T., Kirchner, G., Resch, K

When free radicals come into contact with molecules, they take an electron, which causes cell and DNA damage

mTOR is a key player in pathways that control cell growth

Similarly, in a liver ischemiareperfusion model, mTOR-deficient mice or those treated with rapamycin displayed greater histopathological damage, elevated alanine transaminase and lactate dehydrogenase levels, and increased caspase-3 activation and NF-B translocation [37]

There is a general consensus that the protein requirements of this population are underestimated and it was suggested that a total of 15% of the energy requirements of this population be supplied by proteins

Thus, the GST family represents a promising target for further treatment strategies in childhood RMS (Seitz et al., 2010)