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In terms of side effects and tolerability, the advantage goes to NAD+

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The activated HIFs is able to induce the expression of various gene products, such as glycolysis- and EMT program-associated molecules (CXCR4, SNAIL and TWIST), the induced pluripotency-associated transcription factors (OCT-3/4, NANOG, and SOX2), angiogenic factors (VEGF) and microRNAs, which are vital to self-renewal, survival, invasion, metastasis, angiogenesis, metabolic reprogram, and treatment resistance of cancer cells

Ito, T., Horinouchi, A., Ozaki, H., Imawaka, M., Shirotsuka, Y., and Ando, T