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In the low-concentration group, 12/20 patients had an alternative diagnosis, including 1 LE with anti-GABAbR and a pancreatic adenocarcinoma and 1 progressive encephalomyelitis with rigidity and myoclonus with anti-GlyR without an associated tumor, different variants of subacute or chronic polyradiculoneuropathies, and other nonimmune-mediated diseases (glioblastoma, hemispastic syndrome after brain surgery, multiple system atrophy, or functional disorder)

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Subsequent choices of interface parameters and functional module combinations are, in essence, concrete routes through which these overarching aims are pursued, and they form the basis for the design logic outlined in the following subsections [9, 31, 33, 37]

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TABLE 3 Clinical trials of natural products for treating EMs

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