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doi: 10.3389/fimmu.2025.1643017 Received 07 June 2025 Accepted 31 August 2025 Published 17 September 2025 Volume 16 - 2025 Edited by Hai Fang, Shanghai Jiao Tong University, China Reviewed by Zhi Li, Shanghai University of Traditional Chinese Medicine, China Xinmei Dong, BeiGene, China Updates Copyright 2025 Du, Xiao, Guojun, Dai, Li, Zhao, Zhang, Yang, Liu, Hu, Wen, Zhou, Dai, Zhang and Zhang