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41 Other factors contributing to poor adherence include complex medication schedules, polypharmacy, adverse drug reactions, forgetfulness, poor communication with healthcare providers, and lack of patient education and support

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The exquisite immune specificity for beta cells suggests that such cells may already harbour molecular signatures of vulnerability, which may act not only as initiators or conduits for the early immune response but also as amplifiers of ongoing beta cell-directed immune destruction (Kracht et al