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In regulating lipid metabolism, betaine can directly inhibit primary lipogenesis genes, including diacylglycerol O-acyltransferase 1/2, SREBP-1c, and FAS, while upregulating factors, such as PGC-1, thereby synergistically enhancing alcohol-induced liver lipid accumulation (117, 118) (Figure 5C)

This may suggest that the reduction in free estrogen levels is a result of increased sulphate and glucuronide conjugation or increased oxidation via the estrogen biotransformation pathway

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