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This paper also reviews additional antioxidants diminished in MDD, including albumin, zinc, tryptophan, tyrosine, and glutathione

Glutathione is, therefore, probably involved in the molecular recognition of the electrophilic substrate and should be considered when designing drugs to inhibit GST

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Unfortunately, owing to the heterogeneous permeability of tumours, some drugs do not diffuse effectively, which limits passive targeting

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