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It is imperative to elucidate the physiological alterations necessitated to establish a period of heightened sensitivity or susceptibility to disease, as well as the underlying mechanisms

Diabetes Care, 41(12), 2669-2701

One directly affects the somatotropic cells of the anterior pituitary, itself inhibiting further release of GH, whilst the other affects GH releasing hormone and somatostatin release from the hypothalamus to reduce the secretion of GH