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In zinc oxide nanoparticles-induced human neuroblastoma SH-SY5Y cells, esculetin (10-30 M) can decrease GPx and GSH depletion by inhibiting lipoxygenase expression, which ameliorates the ROS accumulation-induced apoptosis (33)

Bone marrow aspiration or biopsy is a laboratory blood test that examines the pathology of the bone marrow by removing a small sample of bone marrow tissue for microscopic examination of its cellular content and composition to diagnose difficult-to-diagnose hematological diseases such as anemia of unknown cause, leukemia, or aplastic anemia

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In the next article in this series, I cover more about how oxidative stress relates to aging and what we can do about it

The M2 macrophages are characterized as an anti-inflammatory phenotype, demonstrating high Arg-1 expression and producing anti-inflammatory effects (73, 74)

Glossary Pressure overload Pathological state in which the heart has to contract with excessive afterload owing to an increase in arterial pressure