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Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]

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Hirata et al (126) developed hybrid molecules that combine the oxidized indole structure of neuroprotective agents with the polyphenolic structure of curcumin, applying them to mouse hippocampal HT22 cells