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Such low-efficacy compounds may have been incorrectly identified as G protein biased due both to receptor reserve and to the much greater amplification of the G protein signaling arm as compared to the much less sensitive arrestin pathway assays 78

Cardiovascular Protection Attenuates ischemia-reperfusion injury in heart models

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Others need them a little more often at first

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The combination of additional mechanical stimulus plus equal peptide exposure gradually reduces the gap