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vigorous shaking must be avoided

This symptom is heavily driven by neuroinflammation and a breakdown of the blood-brain barrier

K., Tamayo, A

Toxicology 245:194205 Patten CJ, Thomas PE, Guy RL, Lee M, Gonzalez FJ, Guengerich FP, Yang CS (1993) Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics