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J Appl Toxicol JAT 32:505520 Laaksonen R, Katajamaa M, Piv H, Sysi-Aho M, Saarinen L, Junni P, Ltjohann D, Smet J, Van Coster R, Seppnen-Laakso T, Lehtimki T, Soini J, Orei M (2006) A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle

Here, we discuss developments in these two areas, with a focus on liquid biopsy of BM and rational interpretation of variants

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Two-way ANOVA showed significant main effects for cell line ( F 2,38 = 7.251, p = 0.0022) and drug treatment ( F 4,38 = 7.324, p = 0.0002) and a post hoc test showed a significant effect for the highest dose of DTG (p = 0.0011) but not for DTG with ISRIB ( p = 0.7201) when compared to DMSO-treated organoids

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