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10.1210/er.2009-0026 54 HuangQ.ChenH.YinD.WangJ.WangS.YangF.et al (2024)

Research on obese mice showed that chronic AOD-9604 treatment reduced both subcutaneous and visceral fat mass, with visceral reductions being proportionally greater

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The rationale traces back further, to Kraus and colleagues in 2014 ( Nature ), who knocked down NNMT genetically in mice and protected them from diet-induced obesity