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The sample size for this trial was set at 30 for feasibility

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doi: 10.1186/s13045-019-0720-y 12 MaLChenCZhaoCLiTMaLJiangJet al

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TABLE 1 N-acetylcysteine-induced therapeutic effects in psychiatrically relevant rodent models

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Purified IGF-1 and LR3 IGF-1 show bioactivity comparable to the standard IGF-1

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However, their development has been limited by human leukocyte antigen (HLA) restriction and low pMHC presentation levels, resulting in a limited repertoire of well-validated neoantigen peptide-MHC (pMHC) targets 6,7

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