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Analysis of effectiveness of treatment (main outcome) at the three monitoring points Intention-to-treat and per-protocol analyses will both be performed, as is recommended for non-inferiority studies [38]

Clinical Diabetes, 42 (1), 7486

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Cyanocobalamin normalizes the functioning of the liver and nervous system, activates the blood coagulation system, in high doses causes an increase in thromboplastic activity and prothrombin activity

When symptoms occur, they typically relate to underlying conditions such as liver disease, kidney dysfunction, or haematological disorders that cause the elevation, rather than the high B12 itself

Taking cagrilintide injections in the evening allows the most pronounced nausea to occur during sleep