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The GSH molecule consists of glutamic acid, cysteine, and glycine (Gly), with cysteine being the limiting substrate in its formation

Consistent with these findings, a separate study reported that women, irrespective of diagnosis, showed lower ratios of KYNA to 3-HK and QA than men, with these differences further amplified by oral contraceptive use [53]

An important functional difference between these conditions and G6PD deficiency is that the former result from mutations in tissue-specific genes, whereas Gd is a housekeeping gene

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To elucidate the molecular mechanisms underlying MG-induced ferroptosis and kidney injury, we performed an intersection analysis of these differentially expressed genes with known ferroptosis-related gene sets, thereby identifying targeted genes that may be associated with ferroptosis-related mechanisms