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HIF-1 regulates expression of numerous factors linked with angiogenic processes (particularly VEGF), glycolytic enzymes, and pro-metastatic genes

These include: Paraesthesia (pins and needles) in hands and feet Peripheral neuropathy with numbness or altered sensation Difficulty walking or balance problems (ataxia) Memory problems and cognitive difficulties Mood changes, including depression or irritability In severe cases, confusion or dementia-like symptoms Other manifestations may include: Loss of appetite and unintentional weight loss Constipation Visual disturbances (rare, but can occur with optic neuropathy) Important: The neurological complications of B12 deficiency can progress even in the absence of anaemia, making early detection crucial

Spt6 enhances the elongation rate of RNA polymerase II in vivo

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Against this background, this review provides an overview of the structure and function of the bloodbrain barrier and discusses the abnormal changes in the BBB in different CNS diseases