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nevertheless, they have not yet resulted in statistically meaningful, disease-modifying cognitive outcomes

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In chronic kidney disease, loss of kidney epithelial cells leads to glomerulosclerosis and tubular atrophy, whereas interstitial inflammation and fibrosis result from an excess of leukocytes and myofibroblasts

A pathological feature of AD parenchyma is the formation of dystrophic neurites surrounding A plaques, characterized by focal axonal swellings with accumulated autophagic vesicles

Superoxide is then converted to hydrogen peroxide by the antioxidant enzymes superoxide dismutases (SOD1 and SOD2)