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In addition to GSH inhibition, LCS3 is reported to inhibit the activity of thioredoxin reductase1 (TXNRD1), a critical antioxidant regulator maintaining the redox state of thioredoxin (TRX) [19](Supplementary Fig

doi: 10.1111/j.1365-2141.2008

, Wu D., Wu J., et al

Regarding the intake of antioxidant nutrients and their protective effect against AD, it has been found that -carotene can reduce the risk of AD

Most rodent studies use doses in the range of 10 micrograms per kilogram to 10 milligrams per kilogram, administered subcutaneously or intraperitoneally