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Statements Author contributions X-YL collected the related papers and was a major contribution in writing the manuscript

FOX04-DRI & Age-Related Testosterone Production Male late-onset hypogonadism is a condition that occurs with aging and is characterized by the dysfunction of senescent Leydig cells, which are responsible for testosterone production

Note that most Z tables give us the left tailed, CDF, or less than probability

KPV Safety: KPV has been studied mainly in lab research, with limited human safety data available

This comparative assessment serves as a practical reference for selecting or designing nanoparticle systems tailored to specific therapeutic strategies and pathological targets in the treatment of AD