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This hypomethylation suppresses MBP production, compromising myelin stability, similar PADI2 hypomethylation has been observed in PBMCs from MS patients ( IL-17A promoter in T cells increases IL-17 expression, promoting central nervous system inflammation ( 5.1.3 Rheumatoid arthritis Rheumatoid arthritis (RA) is the most common inflammatory arthritis and represents a systemic inflammatory disease that mainly affects the joints ( in vitro stimulation ( Epigenetic mechanisms also contribute to RA, involving histone acetylation, methylation, and DNA methylation

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