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During glutamine deprivation, Teff cells show decreased c-MYC protein expression, growth restriction, and impaired immune function [85].In addition, glutamine deprivation promotes the differentiation of Treg cells through AMPK-mTORC1 signaling pathway, thereby reducing the immune function of Teff cells [86, 87].In summary, the reprogramming of glutamine metabolism in T cells regulates the differentiation and function of T cells from various aspects, thereby regulating the immune response of the body (Fig

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Furthermore, a decrease in the nuclear expression of p jun N-terminal kinase (JNK), p-p38, pIB, and P65 was observed in western blot analysis

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Current Pharmaceutical Design, 26 , 16,18161837(22)