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ROS-mediated oxidation of these exposed residues in a protein may induce a physiological effect upon its activity

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Fontana L, Meyer TE, Klein S, Holloszy JO

doi: 10.1038/s41598-019-43244-0 9 Costa-MallenP.GatenbyC.FriendS.MaravillaK

The buffer-exchanged PGRMC1 wild-type (apo and haem) and PGMRC1 C129S mutants were immediately analysed by nanoflow electrospray ionization MS using gold-coated glass capillaries made in house

Research-Referenced Functional Attributes (Based on existing preclinical and literature datanot intended as claims of therapeutic use) High-affinity binding to HGF and potentiation of c-Met activation in the presence of subthreshold HGF concentrations in cellular assays (DOI: 10.1124/jpet.114.218735) Induction of synaptogenesis and dendritic spine formation through HGF/c-Met pathway augmentation in neuronal models Observation of PI3K/AKT signaling modulation in APP/PS1 mouse models (DOI: 10.3389/fnagi.2021.748253) Investigation of neuroregenerative signaling mechanisms in scopolamine-induced impairment paradigms Examination of synaptic protein expression markers in aging or stress-challenged experimental systems Examination of oral bioavailability and blood-brain barrier penetration in rodent studies