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Awareness of this issue by medical professionals, specifically pharmacists, is particularly important because of the common frequency of exposure of the diabetic population to both metformin and either PPIs or H 2 RAs, especially since the two latter medications are readily available as over-the-counter versions

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Initial investigations typically include liver function tests, renal function assessment, and full blood count

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However, post-marketing surveillance and patient reports suggest that some individuals taking semaglutide do experience leg cramps during treatment