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A pivotal study that highlighted the crucial role of thiamine as an essential nutrient for infant development and discussed how TD phenotype may be confused or overlooked with other diseases was based on an epidemiological investigation on 24- to 39-month-old children presenting repeated vomiting, irritability, and lethargy, without major neurological abnormalities

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In many tissues, but not RBC, these two enzymes are part of the -glutamyl cycle, which is involved with the synthesis and degradation of GSH and is also thought to have a role in amino acid transport across cell membranes

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